A-192621

A-192621

SCHEMBL1030269

CCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 20/20 1.00
EDNRA P25101 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
A-192621 SCHEMBL29551251 1.00 EDNRB (1.00) EDNRBEDNRA
A-192621 SCHEMBL7465738 1.00 EDNRB (1.00) EDNRBEDNRA
A-192621 SCHEMBL3982388 1.00 EDNRB (1.00) EDNRBEDNRA
A-192621 SCHEMBL22404939 1.00 EDNRB (1.00) EDNRBEDNRA
A-192621 SCHEMBL3982386 1.00 EDNRB (1.00) EDNRBEDNRA
SCHEMBL8176298 0.97 EDNRB (0.94) EDNRBEDNRA
SCHEMBL8189498 0.94 EDNRB (1.00) EDNRBEDNRA
SCHEMBL8189503 0.94 EDNRB (1.00) EDNRBEDNRA
SCHEMBL8185019 0.94 EDNRB (1.00) EDNRBEDNRA
SCHEMBL8180058 0.94 EDNRB (1.00) EDNRBEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115251-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF ENDOTHELIN B RECEPTOR EXPRESSING TUMORS ENB THERAPEUTICS INC (US) 2026-04-30 US claimed
US-12337023-B2 Methods and compositions for the prevention and treatment of disease STEALTH BIOTHERAPEUTICS INC. (US) 2025-06-24 US claimed
US-20250082773-A1 COMBINATION THERAPY USING EXOSOME SECRETION INHIBITOR AND IMMUNE CHECKPOINT INHIBITOR Research & Business Foundation Sungkyunkwan University (KR) 2025-03-13 US claimed
US-20250009747-A1 ENDOTHELIN RECEPTOR ANTAGONISTS FOR USE IN TREATING OR PREVENTING MUSCLE FIBROSIS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2025-01-09 US claimed
WO-2024179362-A1 METHODS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION SKELETAL SEQUELAE THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2024-09-06 WO claimed
EP-4422634-A2 ENDOTHELIN RECEPTOR ANTAGONISTS FOR USE IN TREATING OR PREVENTING MUSCLE FIBROSIS Association Institut de Myologie (FR) 2024-09-04 EP claimed
WO-2024141048-A1 METHODS FOR TREATING CORONAVIRUS INFECTIONS THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2024-07-04 WO claimed
CN-116726183-A Compositions and methods for treating cancers associated with ETBR activation ENB治疗公司 2023-09-12 CN claimed
CN-108025035-B Compositions and methods for treating cancers associated with ETBR activation ENB治疗公司 2023-06-13 CN claimed
US-20230094832-A1 ANTIBODY-DRUG CONJUGATE COMPRISING IMMUNE CHECKPOINT INHIBITOR AND EXOSOME SECRETION INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME Research & Business Foundation Sungkyunkwan University (KR) 2023-03-30 US claimed
WO-2022198259-A1 TREATMENT METHODS FOR PULMONARY ARTERIAL HYPERTENSION THE HEART RESEARCH INSTITUTE LTD (AU) 2022-09-29 WO claimed
US-20220265628-A1 TREATMENT OF UROTHELIAL AND KIDNEY CANCERS BY USE OF ENDOTHELIN B RECEPTOR ANTAGONISTS ENB THERAPEUTICS, INC. 2022-08-25 US claimed
US-20220257700-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF ENDOTHELIN B RECEPTOR EXPRESSING TUMORS ENB THERAPEUTICS, INC. 2022-08-18 US claimed
EP-3999062-A1 TREATMENT OF UROTHELIAL AND KIDNEY CANCERS BY USE OF ENDOTHELIN B RECEPTOR ANTAGONISTS ENB Therapeutics, Inc. (US) 2022-05-25 EP claimed
CN-114423425-A Treatment of urothelial and renal cancers by using endothelin B receptor antagonists ENB治疗公司 2022-04-29 CN claimed
US-20170189443-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND CONDITIONS EMPLOYING ORAL ADMINISTRATION OF SODIUM PENTOSAN POLYSULFATE AND OTHER PENTOSAN POLYSULFATE SALTS PLATINUM MONTAUR LIFE SCIENCES, LLC AND AS AGENT (KY) 2017-07-06 US claimed
EP-3110427-A1 COMPOSITIONS OF PENTOSAN POLYSULFATE SALTS FOR ORAL ADMINISTRATION AND METHODS OF USE Urigen Pharmaceuticals, Inc. (US) 2017-01-04 EP claimed
WO-2015127416-A1 COMPOSITIONS OF PENTOSAN POLYSULFATE SALTS FOR ORAL ADMINISTRATION AND METHODS OF USE URIGEN PHARMACEUTICALS, INC. (US) 2015-08-27 WO claimed
US-8173593-B2 Methods and compositions for emergency contraception using endothelin receptor antagonists THE POPULATION COUNCIL, INC. (US) 2012-05-08 US claimed
US-20090203591-A1 Methods and compositions for emergency contraception using endothelin receptor antagonists THE POPULATION COUNCIL, INC. (US) 2009-08-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260115251-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF ENDOTHELIN B RECEPTOR EXPRESSING TUMORS EDNRB, EDNRA, CASP8 EDNRB 1/4885EDNRA 2/4885
US-20230094832-A1 ANTIBODY-DRUG CONJUGATE COMPRISING IMMUNE CHECKPOINT INHIBITOR AND EXOSOME SECRETION INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME EXOSC9, EXOSC5, EXOSC10 EDNRB 3349/4885EDNRA 3304/4885
US-12337023-B2 Methods and compositions for the prevention and treatment of disease COL2A1, ALPI, COL14A1 EDNRB 659/4885EDNRA 1190/4885
US-20220257700-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF ENDOTHELIN B RECEPTOR EXPRESSING TUMORS EDNRB, EDNRA, CASP8 EDNRB 1/4885EDNRA 2/4885
US-20220265628-A1 TREATMENT OF UROTHELIAL AND KIDNEY CANCERS BY USE OF ENDOTHELIN B RECEPTOR ANTAGONISTS EDNRB, EDNRA, UTS2R EDNRB 1/4885EDNRA 2/4885
US-20170189443-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND CONDITIONS EMPLOYING ORAL ADMINISTRATION OF SODIUM PENTOSAN POLYSULFATE AND OTHER PENTOSAN POLYSULFATE SALTS SI, SLC20A1, SLC20A2 EDNRB 1013/4885EDNRA 1450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.