Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517353 | 0.79 | CDK2 (0.52) | CDK2CDK4CCNE1 | |
| SCHEMBL13185630 | 0.78 | IKBKB (0.60) | PLK1NPC1RAB9AJAK2JAK3 | |
| SCHEMBL7474055 | 0.78 | PIK3CA (0.59) | CDK2KDRPTK2PLK1AURKB | |
| SCHEMBL7460307 | 0.76 | SYK (0.55) | SYK | |
| SCHEMBL3518870 | 0.76 | ALDH1A1 (0.51) | CDK2CDK4MAPK10 | |
| SCHEMBL3520839 | 0.76 | CDK2 (0.52) | CDK2CDK4CCNE1 | |
| SCHEMBL7465536 | 0.75 | ABL1 (0.54) | NPC1RAB9AJAK2JAK3SYK | |
| SCHEMBL7475710 | 0.74 | ABL1 (0.71) | — | |
| SCHEMBL4159422 | 0.74 | CDK2 (0.42) | CDK2JAK2JAK3SYKCDK4 | |
| SCHEMBL7459060 | 0.74 | NPC1 (0.46) | CDK2NPC1RAB9AAURKBRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |