Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.60 |
| ▸ | HTR1B | P28222 | 13/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | HTR1F | P30939 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460796 | 0.88 | HTR1D (0.56) | HTR1DHTR1BMAPTBLMNPSR1 | |
| Hydrochloric Acid SCHEMBL8617780 | 0.88 | HTR1D (0.55) | HTR1DHTR1BMAPTBLMNPSR1 | |
| SCHEMBL7461651 | 0.84 | HTR1D (0.52) | HTR1DHTR1BMAPTBLMNPSR1 | |
| SCHEMBL5363538 | 0.79 | CYP1A2 (0.60) | HTR1DHTR1BMAPTBLMNPSR1 | |
| SCHEMBL4799796 | 0.78 | MAPT (0.65) | HTR1DHTR1BMAPTBLMNPSR1 | |
| SCHEMBL7485069 | 0.78 | CYP1A2 (0.68) | HTR1DHTR1BMAPTBLMNPSR1 | |
| SCHEMBL7710792 | 0.78 | HTR1D (0.67) | HTR1DHTR1BMAPTBLMNPSR1 | |
| SCHEMBL7483268 | 0.77 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL1388908 | 0.77 | HTR1B (0.67) | HTR1DHTR1BHTR1A | |
| SCHEMBL1388907 | 0.77 | HTR1B (0.67) | HTR1DHTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782568-B1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PF MEDICAMENT (FR) | 2002-04-24 | — | — | EP | claimed |
| EP-0782568-B1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PF MEDICAMENT (FR) | 2002-04-24 | — | — | EP | disclosed |
| EP-0782568-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009288-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1996-03-28 | — | — | WO | disclosed |