Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.67 |
| ▸ | HTR6 | P50406 | 10/20 | 0.63 |
| ▸ | HTR1D | P28221 | 5/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388908 | 1.00 | HTR1B (0.67) | HTR1BHTR1AHTR6HTR1DCHRM2 | |
| Hydrochloric Acid SCHEMBL8612746 | 0.99 | HTR1B (0.66) | HTR1BHTR1AHTR6HTR1DCHRM2 | |
| SCHEMBL7465775 | 0.89 | HTR1B (0.62) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL8879855 | 0.86 | HTR1B (0.72) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL8617260 | 0.85 | HTR1B (0.70) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL8808971 | 0.85 | HTR1B (0.70) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL8932357 | 0.85 | HTR1B (0.76) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL8932358 | 0.85 | HTR1B (0.76) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL7465779 | 0.85 | HTR1B (0.61) | HTR1BHTR1AHTR6HTR1DCHRM2 | |
| SCHEMBL8615007 | 0.83 | HTR1B (0.67) | HTR1BHTR1AHTR6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782568-B1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PF MEDICAMENT (FR) | 2002-04-24 | — | — | EP | claimed |
| JP-H10505852-A | — | — | 1998-06-09 | — | — | JP | claimed |
| EP-0782568-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1997-07-09 | — | — | EP | claimed |
| WO-1996009288-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1996-03-28 | — | — | WO | claimed |
| EP-0782568-B1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PF MEDICAMENT (FR) | 2002-04-24 | — | — | EP | disclosed |
| EP-0782568-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009288-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1996-03-28 | — | — | WO | disclosed |