Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682035 | 1.00 | POLB (0.44) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL5682124 | 0.93 | POLB (0.45) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL7980355 | 0.90 | POLB (0.43) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL7980357 | 0.90 | POLB (0.43) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL17756093 | 0.87 | POLB (0.43) | POLBMAPTLTA4HSYK | |
| SCHEMBL5677953 | 0.85 | PSMB5 (0.40) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL5682158 | 0.85 | PSMB5 (0.40) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL9327711 | 0.84 | CTSK (0.48) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL5187344 | 0.83 | CTSK (0.47) | POLBCTSKGAAMAPTXBP1 | |
| SCHEMBL5188450 | 0.83 | CTSK (0.47) | POLBCTSKGAAMAPTXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0981521-B1 | NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-12-11 | — | — | EP | disclosed |
| US-6281352-B1 | ANTIINFLAMMATORY AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-08-28 | — | — | US | disclosed |