Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 14/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.59 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830039 | 1.00 | GRIN2B (0.59) | GRIN2BGRIN1NOS2NPC1GRIN2D | |
| SCHEMBL15939937 | 0.82 | KMT2A (0.48) | GRIN2BGRIN1NPC1 | |
| SCHEMBL15939913 | 0.82 | KMT2A (0.48) | GRIN2BGRIN1NPC1 | |
| SCHEMBL9133458 | 0.82 | NPC1 (0.50) | GRIN2BNOS2NPC1SIGMAR1 | |
| SCHEMBL9133454 | 0.82 | NPC1 (0.50) | GRIN2BNOS2NPC1SIGMAR1 | |
| SCHEMBL9213789 | 0.80 | NOS2 (0.52) | NOS2NPC1 | |
| SCHEMBL9680009 | 0.80 | NOS2 (0.52) | NOS2NPC1 | |
| SCHEMBL7455552 | 0.79 | GRIN2B (0.41) | GRIN2BGRIN1 | |
| SCHEMBL7455546 | 0.79 | GRIN2B (0.41) | GRIN2BGRIN1 | |
| SCHEMBL5075641 | 0.77 | GRIN2B (0.63) | GRIN2BGRIN1NOS2NPC1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0947510-B1 | Process for the preparation of 1,3,4-trisubstituted 1,2,4-triazolium salts | BASF AG (DE) | 2002-02-13 | — | — | EP | disclosed |
| EP-0714897-B1 | FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | BANYU PHARMA CO LTD (JP) | 2001-02-14 | — | — | EP | disclosed |
| EP-0947510-A1 | Process for the preparation of 1,3,4-trisubstituted 1,2,4-triazolium salts | BASF AKTIENGESELLSCHAFT (DE) | 1999-10-06 | — | — | EP | disclosed |
| US-5714479-A | TREATMENT OF HYPERTENSION, ACUTE RENAL FAILURE, ANGINA PECTORIS, ARTERIOSCLEROSIS, ASTHMA, GASTRIC ULCER AND SIMILAR AILMENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-02-03 | — | — | US | disclosed |
| EP-0714897-A1 | FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-06-05 | — | — | EP | disclosed |