Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.72 |
| ▸ | ABL1 | P00519 | 5/20 | 0.71 |
| ▸ | PRKCA | P17252 | 4/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.71 |
| ▸ | EGFR | P00533 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | PRKCG | P05129 | 1/20 | 0.68 |
| ▸ | PRKCB | P05771 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | PRKCH | P24723 | 1/20 | 0.68 |
| ▸ | PRKCI | P41743 | 1/20 | 0.68 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.68 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.68 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.68 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897346 | 0.89 | ABL1 (0.67) | ABL1PRKCAPRKCDEGFRKMT2A | |
| SCHEMBL7474612 | 0.86 | PIK3CG (0.76) | ABL1PRKCAPRKCDEGFRMEN1 | |
| SCHEMBL7465398 | 0.85 | PIK3CG (0.76) | ACVR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4903391 | 0.83 | ABL1 (0.66) | ABL1PRKCAPRKCDEGFRPRKD3 | |
| SCHEMBL6262145 | 0.83 | ABL1 (1.00) | ABL1PRKCAPRKCDEGFRNPC1 | |
| SCHEMBL3868291 | 0.82 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRMEN1 | |
| SCHEMBL7461475 | 0.82 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRMEN1 | |
| SCHEMBL10977837 | 0.82 | PIK3CG (0.78) | ABL1PRKCAPRKCDEGFRMEN1 | |
| SCHEMBL7464205 | 0.82 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRPRKD3 | |
| SCHEMBL7476133 | 0.82 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |