Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.76 |
| ▸ | ABL1 | P00519 | 10/20 | 0.72 |
| ▸ | BCR | P11274 | 8/20 | 0.72 |
| ▸ | SRC | P12931 | 4/20 | 0.70 |
| ▸ | PRKCA | P17252 | 7/20 | 0.68 |
| ▸ | EGFR | P00533 | 6/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.68 |
| ▸ | PRKACA | P17612 | 1/20 | 0.68 |
| ▸ | PRKACG | P22612 | 1/20 | 0.68 |
| ▸ | PRKACB | P22694 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | PRKCG | P05129 | 1/20 | 0.67 |
| ▸ | PRKCB | P05771 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | PRKCH | P24723 | 1/20 | 0.67 |
| ▸ | PRKCI | P41743 | 1/20 | 0.67 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.67 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116598 | 0.90 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBEGFRPRKD3 | |
| SCHEMBL7464195 | 0.88 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL7466239 | 0.86 | ACVR1 (0.72) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL2942460 | 0.85 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBEGFRPRKD3 | |
| SCHEMBL8255847 | 0.85 | PIK3CG (0.59) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL1704 | 0.85 | ABL1 (0.65) | PIK3CGPIK3CAABL1BCRSRC | |
| SCHEMBL2939794 | 0.84 | CDK5 (0.80) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL4084867 | 0.84 | ABL1 (0.77) | ABL1BCRSRCPRKCAEGFR | |
| SCHEMBL7476769 | 0.84 | ABL1 (1.00) | PIK3CGPIK3CAABL1BCRSRC | |
| SCHEMBL27116705 | 0.84 | PIK3CG (0.73) | PIK3CGPIK3CAPIK3CBABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |