Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847229 | 0.84 | MAPK1 (0.53) | SMN1; SMN2HPGDHTTKDM4EFAAH | |
| SCHEMBL19223897 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTKDM4ETSHR | |
| SCHEMBL31632735 | 0.83 | DGKA (0.56) | SMN1; SMN2HPGDHTTFAAHMGLL | |
| SCHEMBL31632764 | 0.83 | DGKA (0.56) | SMN1; SMN2HPGDHTTFAAHMGLL | |
| SCHEMBL31632750 | 0.83 | DGKA (0.56) | SMN1; SMN2HPGDHTTFAAHMGLL | |
| SCHEMBL31632719 | 0.83 | DGKA (0.56) | SMN1; SMN2HPGDHTTFAAHMGLL | |
| SCHEMBL31632693 | 0.83 | DGKA (0.56) | SMN1; SMN2HPGDHTTFAAHMGLL | |
| SCHEMBL31632743 | 0.83 | DGKA (0.56) | SMN1; SMN2HPGDHTTFAAHMGLL | |
| SCHEMBL31632698 | 0.83 | DGKA (0.56) | SMN1; SMN2HPGDHTTFAAHMGLL | |
| SCHEMBL10432974 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDHTTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874842-B1 | MERCAPTOALKYLPEPTIDYL COMPOUNDS HAVING AN IMIDAZOLE SUBSTITUENT AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES (MMP) AND/OR TUMOUR NECROSIS FACTOR (TNF) | DARWIN DISCOVERY LTD (GB) | 2002-04-10 | — | — | EP | disclosed |
| US-6048841-A | ENZYME INHIBITOR; ANTAGONIST AGAINST TUMOR NECROSIS FACTOR | DARWIN DISCOVERY, LTD. (GB) | 2000-04-11 | — | — | US | disclosed |
| EP-0874842-A1 | MERCAPTOALKYLPEPTIDYL COMPOUNDS HAVING AN IMIDAZOLE SUBSTITUENT AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES (MMP) AND/OR TUMOUR NECROSIS FACTOR (TNF) | Darwin Discovery Limited (GB) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997019075-A1 | MERCAPTOALKYLPEPTIDYL COMPOUNDS HAVING AN IMIDAZOLE SUBSTITUENT AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES (MMP) AND/OR TUMOUR NECROSIS FACTOR (TNF) | DARWIN DISCOVERY LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |