Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.74 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.60 |
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CA3 | P07451 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955360 | 0.88 | PTGS2 (0.74) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL3242046 | 0.88 | PTGS2 (0.74) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL15346803 | 0.87 | PTGS2 (0.77) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL6720876 | 0.87 | PTGS2 (0.59) | PTGS2CYP2C9PTGS1PDPK1 | |
| SCHEMBL6957077 | 0.86 | PTGS2 (0.80) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL6730098 | 0.86 | PTGS2 (0.60) | PTGS2CYP2C9PTGS1PDPK1 | |
| SCHEMBL15346781 | 0.86 | PTGS2 (0.75) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL5148804 | 0.85 | PTGS2 (0.66) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL5229949 | 0.85 | PTGS2 (1.00) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL5148756 | 0.85 | PTGS2 (0.66) | PTGS2CYP2C9PTGS1PDPK1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554829-B1 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-05-15 | — | — | EP | disclosed |
| US-5670533-A | ANTIINFLAMMATORY AGENTS, ANALGESICS OR ANTIRHEUMATIC DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-5550147-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTITHROMBOTIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0554829-A2 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |