Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 9/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6707885 | 0.89 | KIF11 (0.48) | RXFP1KIF11HTR2ATSPOGPR183 | |
| SCHEMBL6709302 | 0.89 | FLT1 (0.51) | FLT1KDRRXFP1 | |
| SCHEMBL6708053 | 0.76 | FLT1 (0.46) | FLT1KDRRXFP1P2RX1 | |
| SCHEMBL6707907 | 0.76 | FLT1 (0.45) | FLT1KDR | |
| SCHEMBL6707219 | 0.75 | SMN1; SMN2 (0.56) | FLT1KDRHTR2ATRPV1P2RX1 | |
| SCHEMBL6707083 | 0.74 | KIF11 (0.43) | RXFP1KIF11HTR2ATSPOGPR183 | |
| SCHEMBL6709110 | 0.72 | KIF11 (0.43) | RXFP1KIF11HTR2ATSPOGPR183 | |
| SCHEMBL29458439 | 0.71 | MEN1 (0.55) | FLT1KDRTRPV1 | |
| SCHEMBL6709304 | 0.69 | KIF11 (0.48) | RXFP1KIF11HTR2ATRPV1P2RX1 | |
| SCHEMBL6707284 | 0.69 | FLT1 (0.51) | FLT1KDRRXFP1HTR2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012150-A4 | HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS | SUGEN INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1012150-A1 | HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS | Sugen, Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998052944-A1 | HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS | SUGEN, INC. (US) | 1998-11-26 | — | — | WO | disclosed |