Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457200 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAALDH1A1MAPK1GFER | |
| SCHEMBL7464168 | 0.96 | BCHE (0.41) | SMN1; SMN2LMNAALDH1A1MAPK1GFER | |
| SCHEMBL7456178 | 0.96 | BCHE (0.41) | SMN1; SMN2LMNAALDH1A1MAPK1GFER | |
| SCHEMBL7455507 | 0.92 | MAPT (0.40) | SMN1; SMN2LMNAALDH1A1MAPK1GFER | |
| SCHEMBL7461319 | 0.92 | MAPT (0.40) | SMN1; SMN2LMNAALDH1A1MAPK1GFER | |
| SCHEMBL7461037 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAALDH1A1MAPK1GFER | |
| SCHEMBL7458035 | 0.82 | GAA (0.40) | SMN1; SMN2LMNAALDH1A1MAPK1BCHE | |
| SCHEMBL7458042 | 0.82 | GAA (0.40) | SMN1; SMN2LMNAALDH1A1MAPK1BCHE | |
| SCHEMBL7461047 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAALDH1A1MAPK1GFER | |
| SCHEMBL7456570 | 0.81 | SIGMAR1 (0.48) | SMN1; SMN2LMNAALDH1A1MAPK1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891976-B1 | Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents | PROCTER & GAMBLE PHARMA (US) | 2002-10-16 | — | — | EP | disclosed |
| US-6083945-A | USEFUL IN TREATING HUMANS OR OTHER MAMMALS WITH CARDIAC ARRHYTHMIA AND/OR CARDIAC FIBRILLATION | THE PROCTER & GAMBLE COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0598046-B1 | CYCLIC UREAS USEFUL AS ANTIARRHYTHMIC AND ANTIFIBRILLATORY AGENTS | PROCTER & GAMBLE PHARMA (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0891976-A1 | Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents | PROCTER & GAMBLE PHARMACEUTICALS (US) | 1999-01-20 | — | — | EP | disclosed |