Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960571 | 0.87 | NOTUM (0.40) | BRPF1NOTUMPBRM1BRD4CYP1A2 | |
| SCHEMBL29750764 | 0.82 | CCNC (0.51) | SMN1; SMN2MAPTHTTMAP2SGK1 | |
| SCHEMBL9748278 | 0.74 | NOTUM (0.50) | SMN1; SMN2MAPTHTTRPA1MCL1 | |
| SCHEMBL1585807 | 0.73 | RPA1 (0.51) | MAPTHTTMAP2RPA1MCL1 | |
| SCHEMBL15197092 | 0.72 | ALDH1A1 (0.44) | SMN1; SMN2MAPTBRPF1PBRM1RAB9A | |
| SCHEMBL7687945 | 0.71 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTHTTNOTUMCYP1A2 | |
| SCHEMBL14023416 | 0.69 | NOTUM (0.48) | SMN1; SMN2MAPTBRPF1NOTUMBRD4 | |
| SCHEMBL20157257 | 0.69 | CCNC (0.51) | SMN1; SMN2NOTUM | |
| Biphenyl SCHEMBL15332958 | 0.68 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTHTTRAB9AKMO | |
| Biphenyl SCHEMBL1822628 | 0.68 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTHTTRAB9AKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674879-A | Compositions including and methods of using conformationally restricted angiotensin II antagonist | G.D. SEARLE & CO. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5426105-A | Cardiovascular disorders | G.D. SEARLE & CO. (US) | 1995-06-20 | — | — | US | disclosed |