⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28379513 | 0.98 | AXL (0.38) | — | |
| SCHEMBL360202 | 0.77 | — | — | |
| SCHEMBL13562934 | 0.77 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL31441719 | 0.77 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL7468377 | 0.77 | GRM5 (0.43) | — | |
| SCHEMBL23131223 | 0.75 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL40201 | 0.74 | RRM2 (0.40) | — | |
| SCHEMBL30671581 | 0.74 | — | — | |
| SCHEMBL292777 | 0.74 | — | — | |
| SCHEMBL29828009 | 0.74 | RRM2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466258-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-11-27 | — | — | EP | disclosed |
| US-20240383875-A1 | Benzimidazole Pyridine Derivatives | HOFFMANN-LA ROCHE INC. (US) | 2024-11-21 | — | — | US | disclosed |
| CN-118591534-A | Novel benzimidazole pyridine derivatives | 豪夫迈·罗氏有限公司 | 2024-09-03 | — | — | CN | disclosed |
| WO-2023139085-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |
| CN-106103416-B | Azaspiro derivatives as TRPM8 antagonists | 拉夸里亚创药株式会社 | 2021-03-02 | — | — | CN | disclosed |
| CN-111051305-A | Therapeutic heterocyclic compounds | 吉利德科学公司 | 2020-04-21 | — | — | CN | disclosed |
| EP-2788335-B1 | 5-(3-AMINOPHENYL)-5-ALKYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES FOR THE TREATMENT OF DISORDERS IN WHICH BETA-SECRETASE IS INVOLVED | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-13 | — | — | EP | disclosed |
| CN-102781923-B | 5-alkynyl-pyrimidines compound | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-02 | — | — | CN | disclosed |
| CN-102574845-B | 1H-imidazo [4,5-c] qualone derivative | NOVARTIS AG (CH) | 2015-09-02 | — | — | CN | disclosed |
| US-20140364428-A1 | 5-(3-AMINOPHENYL)-5-ALKYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (US) | 2014-12-11 | — | — | US | disclosed |
| WO-2013083556-A1 | 5-(3-AMINOPHENYL)-5-ALKYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-13 | — | — | WO | disclosed |
| CN-102781931-A | 5-alkynyl pyrimidines and their use as kinase inhibitors | BOEHRINGER INGELHEIM INT | 2012-11-14 | — | — | CN | disclosed |
| EP-0963986-B1 | 5,10-Dihydrodipyrido(2,3-b:2,3-e)pyrazine and 5,10-dihydro(2,3-b:3,2-e)pyrazine, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-04-17 | — | — | EP | disclosed |
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| EP-0963986-A2 | 5,10-Dihydrodipyrido(2,3-b:2,3-e)pyrazine and 5,10-dihydro(2,3-b:3,2-e)pyrazine, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-12-15 | — | — | EP | disclosed |