SCHEMBL7467101

SCHEMBL7467101

COc1ccc2[nH]cc(C=C(C#N)C(N)=O)c2c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2C9 P11712 1/20 0.62
MAPT P10636 5/20 0.59
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
POLB P06746 2/20 0.59
NPSR1 Q6W5P4 2/20 0.59
ALDH1A1 P00352 5/20 0.56
CYP2C19 P33261 1/20 0.56
MTNR1A P48039 2/20 0.53
MTNR1B P49286 2/20 0.53
RAB9A P51151 2/20 0.51
NPC1 O15118 1/20 0.51
KDM4E B2RXH2 2/20 0.49
NR4A2 P43354 1/20 0.48
CLK1 P49759 2/20 0.47
DYRK1A Q13627 2/20 0.47
MITF O75030 1/20 0.46
LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7467095 1.00 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9MAPTMEN1
SCHEMBL7456833 0.83 EGFR (0.60) CYP1A2CYP3A4CYP2C9MAPTMEN1
SCHEMBL7471108 0.83 POLB (0.49) CYP1A2CYP3A4CYP2C9MAPTMEN1
SCHEMBL7471104 0.83 POLB (0.49) CYP1A2CYP3A4CYP2C9MAPTMEN1
SCHEMBL7456830 0.83 EGFR (0.60) CYP1A2CYP3A4CYP2C9MAPTMEN1
SCHEMBL7460312 0.82 MAPT (0.63) CYP1A2MAPTMEN1KMT2APOLB
SCHEMBL7460308 0.82 MAPT (0.63) CYP1A2MAPTMEN1KMT2APOLB
SCHEMBL7466929 0.81 ALDH1A1 (0.51) CYP1A2CYP3A4CYP2C9MAPTMEN1
SCHEMBL7466924 0.81 ALDH1A1 (0.51) CYP1A2CYP3A4CYP2C9MAPTMEN1
SCHEMBL7471825 0.79 MAPT (0.60) MAPTMEN1KMT2APOLBNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700388-B1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2002-09-18 EP claimed
EP-0700388-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1996-03-13 EP claimed
WO-1995026341-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA S.P.A. (IT) 1995-10-05 WO claimed
EP-0700388-B1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2002-09-18 EP disclosed
US-5652250-A TYROSINE KINASE INHIBITORS PHARMACIA S.P.A. (IT) 1997-07-29 US disclosed
EP-0700388-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1996-03-13 EP disclosed
WO-1995026341-A1 SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS PHARMACIA S.P.A. (IT) 1995-10-05 WO disclosed