Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 7/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 5/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476134 | 0.90 | CDK4 (0.40) | EGFRRPS6KA6CDK4AURKACDK1 | |
| SCHEMBL7468092 | 0.90 | EGFR (0.38) | EGFRRPS6KA6CDK4CDK1CCND1 | |
| SCHEMBL7467084 | 0.88 | JAK3 (0.38) | EGFRRPS6KA6CDK4CDK1KDR | |
| SCHEMBL7463354 | 0.85 | ERBB3 (0.41) | EGFRCDK4AURKACDK1INSR | |
| SCHEMBL7469937 | 0.85 | CDK4 (0.41) | EGFRCDK4AURKACDK1INSR | |
| SCHEMBL7462456 | 0.84 | SYK (0.43) | EGFRCDK4AURKACDK1INSR | |
| SCHEMBL6087101 | 0.83 | SYK (0.44) | EGFRCDK4CDK1CCND1CCNE1 | |
| SCHEMBL6087785 | 0.81 | SYK (0.43) | EGFRCDK4CDK1CCND1CCNE1 | |
| SCHEMBL6087449 | 0.81 | CDK4 (0.46) | EGFRCDK4AURKACDK1INSR | |
| SCHEMBL7464943 | 0.81 | EGFR (0.39) | EGFRRPS6KA6CDK4AURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | disclosed |