Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 5/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | CTSG | P08311 | 3/20 | 0.35 |
| ▸ | CMA1 | P23946 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466135 | 0.87 | PARL (0.38) | AVPR1BAKR1B1CTSGCMA1POLB | |
| SCHEMBL7472235 | 0.84 | NPSR1 (0.36) | AVPR1BAVPR1ACYP3A4ALOX15TSHR | |
| SCHEMBL7470216 | 0.83 | GAA (0.47) | POLBMEN1KMT2AAVPR2 | |
| SCHEMBL7470710 | 0.79 | GAA (0.46) | AVPR1BPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL7466648 | 0.76 | NPSR1 (0.45) | AVPR1BMEN1KMT2AMAPT | |
| SCHEMBL7475235 | 0.74 | AVPR1B (0.45) | AVPR1BAVPR1AAVPR2OXTR | |
| SCHEMBL8589677 | 0.74 | AVPR1B (0.40) | AVPR1BAVPR1ACYP3A4ALOX15TSHR | |
| SCHEMBL7467205 | 0.74 | AVPR1B (0.46) | AVPR1BAVPR1ACYP3A4ALOX15TSHR | |
| SCHEMBL7472067 | 0.74 | AVPR1B (0.44) | AVPR1BAVPR1ACYP3A4ALOX15TSHR | |
| SCHEMBL7471625 | 0.73 | NPSR1 (0.41) | AVPR1BMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5773612-A | VASOPRESSIN OR OXYTOCIN RECEPTORS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |