PARL
Presenilin-associated rhomboid-like protein, mitochondrial · Q9H300 · PARL on Sugi Atlas →
2,393 patent compounds predicted against PARL, 1,075 high-confidence (nearest known ligand ≥ 0.5)
Top predicted compounds (top 20 by supporting neighbours, then confidence)
| Compound | Confidence | Supporting neighbours | |
|---|---|---|---|
| SCHEMBL12339094 | 0.81 | 5/20 | |
| SCHEMBL64964 | 1.00 | 4/20 | |
| SCHEMBL7973261 | 1.00 | 4/20 | |
| SCHEMBL11402547 | 1.00 | 4/20 | |
| SCHEMBL65876 | 0.86 | 4/20 | |
| SCHEMBL7973267 | 0.65 | 4/20 | |
| SCHEMBL5367011 | 0.62 | 4/20 | |
| SCHEMBL1606492 | 0.59 | 4/20 | |
| SCHEMBL7161148 | 0.58 | 4/20 | |
| SCHEMBL64963 | 0.53 | 4/20 | |
| SCHEMBL11765374 | 0.52 | 4/20 | |
| SCHEMBL64814 | 0.50 | 4/20 | |
| SCHEMBL64828 | 0.50 | 4/20 | |
| SCHEMBL1702307 | 0.50 | 4/20 | |
| SCHEMBL3087267 | 0.50 | 4/20 | |
| Pyridine (SCHEMBL9065176) | 0.50 | 4/20 | |
| SCHEMBL812586 | 0.41 | 4/20 | |
| SCHEMBL11381247 | 0.41 | 4/20 | |
| Succinchlorimide (SCHEMBL312793) | 0.38 | 4/20 | |
| SCHEMBL313161 | 0.38 | 4/20 |
Clinical trials — most relevant to PARL by text similarity (a relevance ranking, not an exhaustive list)
Related proteins — ESM-2 sequence neighbours (a PARL binder may also engage these)
| Protein | Name | Similarity | |
|---|---|---|---|
| Q5R5H4 | — | 1.000 | Q5R5H4 → |
| Q2KHV4 | — | 1.000 | Q2KHV4 → |
| Q5XJY4 | — | 1.000 | Q5XJY4 → |
| Q3B8P0 | — | 0.999 | Q3B8P0 → |
| Q58EK4 | — | 0.955 | Q58EK4 → |
| Q5R460 | — | 0.950 | Q5R460 → |
| Q12887 | — | 0.945 | Q12887 → |
| Q8CFY5 | — | 0.944 | Q8CFY5 → |
| P09925 | — | 0.943 | P09925 → |
| MCU | Calcium uniporter protein, mitochondrial | 0.943 | landscape → |
| Q5SRD1 | — | 0.942 | Q5SRD1 → |
| Q9QXU2 | — | 0.941 | Q9QXU2 → |
| O14925 | — | 0.940 | O14925 → |
| Q6P4H8 | — | 0.940 | Q6P4H8 → |
| Q99KU0 | — | 0.940 | Q99KU0 → |
| Q15526 | — | 0.939 | Q15526 → |
| D3ZLY0 | — | 0.939 | D3ZLY0 → |
| Q3UMR5 | — | 0.939 | Q3UMR5 → |
| TIMM44 | Mitochondrial import inner membrane translocase subunit TIM44 | 0.939 | landscape → |
| Q5R9K4 | — | 0.939 | Q5R9K4 → |
| Q6INE8 | — | 0.939 | Q6INE8 → |
| Q9JI99 | — | 0.939 | Q9JI99 → |
| Q8RXW0 | — | 0.939 | Q8RXW0 → |
| O35093 | — | 0.939 | O35093 → |
| Q6INU6 | — | 0.938 | Q6INU6 → |
| Q9D1Z3 | — | 0.938 | Q9D1Z3 → |
| Q0VCK9 | — | 0.938 | Q0VCK9 → |
| Q5XH94 | — | 0.937 | Q5XH94 → |
| Q9ERM3 | — | 0.937 | Q9ERM3 → |
| Q68EQ9 | — | 0.937 | Q68EQ9 → |