Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | RRM1 | P23921 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8859582 | 1.00 | MAPT (0.63) | MAPTALDH1A1KDM4ESMN1; SMN2RRM1 | |
| SCHEMBL3246996 | 0.84 | APP (0.56) | MAPTALDH1A1RRM1POLBRXFP3 | |
| SCHEMBL7456833 | 0.82 | EGFR (0.60) | MAPTALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL7471104 | 0.82 | POLB (0.49) | MAPTALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL7471108 | 0.82 | POLB (0.49) | MAPTALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL7456830 | 0.82 | EGFR (0.60) | MAPTALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL7466924 | 0.80 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL7466929 | 0.80 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL5635746 | 0.78 | MAPT (0.49) | MAPTRRM1POLBRXFP3MEN1 | |
| SCHEMBL5635744 | 0.78 | MAPT (0.49) | MAPTRRM1POLBRXFP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-5652250-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1997-07-29 | — | — | US | disclosed |