Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224089 | 0.94 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL7463257 | 0.94 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL7223488 | 0.92 | CRHR1 (0.79) | CRHR1 | |
| SCHEMBL7468530 | 0.90 | CRHR1 (0.83) | CRHR1 | |
| SCHEMBL7466837 | 0.90 | CRHR1 (0.71) | CRHR1 | |
| SCHEMBL7223034 | 0.89 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL7223033 | 0.89 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL7470050 | 0.89 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL7227213 | 0.87 | CRHR1 (0.71) | CRHR1 | |
| SCHEMBL7466344 | 0.87 | CRHR1 (0.71) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012151-B1 | HETEROCYCLYL-SUBSTITUTED RING-FUSED PYRIDINES AND PYRIMIDINES AS CORTICOTROPIN RELEASING HORMONE (CRH) ANTAGONISTS, USEFUL FOR TREATING CNS AND STRESS-RELATED DISORDERS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-08-07 | — | — | EP | claimed |