Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 8/20 | 0.48 |
| ▸ | ESR1 | P03372 | 8/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028656 | 0.97 | HRAS (0.49) | HRASESR1ESR2HDAC1HDAC2 | |
| SCHEMBL7467693 | 0.88 | HRAS (0.47) | HRASESR1ESR2HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL7470484 | 0.88 | HRAS (0.47) | HRASESR1ESR2HDAC1HDAC2 | |
| SCHEMBL7472023 | 0.88 | HRAS (0.51) | HRASESR1ESR2EGFRERBB2 | |
| SCHEMBL8605051 | 0.86 | HDAC1 (0.42) | HRASESR1ESR2HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL7466261 | 0.85 | HRAS (0.49) | HRASESR1ESR2EGFRERBB2 | |
| SCHEMBL7471663 | 0.85 | HRAS (0.46) | HRASESR1ESR2HDAC1HDAC2 | |
| SCHEMBL8298671 | 0.84 | HRAS (0.46) | HRASESR1ESR2EGFRERBB2 | |
| SCHEMBL8602914 | 0.83 | HRAS (0.42) | HRASESR1ESR2HDAC1HDAC2 | |
| SCHEMBL7478831 | 0.81 | HRAS (0.43) | HRASESR1ESR2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |