Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418840 | 1.00 | PARP1 (0.49) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL7419362 | 0.81 | KIF11 (0.55) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL7467512 | 0.78 | KIF11 (0.51) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL7421225 | 0.77 | KIF11 (0.50) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL7473716 | 0.77 | KIF11 (0.50) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL7422800 | 0.76 | KMT2A (0.58) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL7418777 | 0.74 | KMT2A (0.48) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL4725998 | 0.73 | KIF11 (0.84) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL29708168 | 0.73 | KIF11 (0.84) | PARP1KIF11RAB9ACSNK2A1KMT2A | |
| SCHEMBL7423919 | 0.72 | KMT2A (0.46) | PARP1KIF11RAB9ACSNK2A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |