Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.71 |
| ▸ | PRKCA | P17252 | 7/20 | 0.71 |
| ▸ | EGFR | P00533 | 4/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.71 |
| ▸ | BCR | P11274 | 11/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 3/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | PRKACG | P22612 | 1/20 | 0.58 |
| ▸ | PRKACB | P22694 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
| ▸ | PRKCB | P05771 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7467281 | 0.99 | ABL1 (0.69) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL4138273 | 0.89 | ABL1 (0.57) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL7467187 | 0.85 | CDK2 (0.60) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL6262145 | 0.83 | ABL1 (1.00) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL7476133 | 0.82 | ABL1 (0.76) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL7464205 | 0.82 | ABL1 (0.76) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL3868291 | 0.82 | ABL1 (0.76) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL7461475 | 0.82 | ABL1 (0.76) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL29618427 | 0.82 | ABL1 (0.85) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL7474975 | 0.82 | ABL1 (0.71) | ABL1PRKCAEGFRPRKCDBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |