Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468742 | 1.00 | MIF (0.58) | MIFMEN1KMT2ACTDSP1PIN1 | |
| SCHEMBL8306398 | 0.88 | MIF (0.50) | MIFMEN1KMT2ACTDSP1PIN1 | |
| SCHEMBL8470843 | 0.88 | MIF (0.50) | MIFMEN1KMT2ACTDSP1PIN1 | |
| SCHEMBL23797235 | 0.88 | MIF (0.76) | MIFMEN1KMT2ANPC1RAB9A | |
| SCHEMBL23797233 | 0.88 | MIF (0.76) | MIFMEN1KMT2ANPC1RAB9A | |
| SCHEMBL13201425 | 0.88 | MIF (0.76) | MIFMEN1KMT2ANPC1RAB9A | |
| SCHEMBL13925571 | 0.87 | MIF (0.66) | MIFMEN1KMT2ACTDSP1PIN1 | |
| SCHEMBL13925577 | 0.87 | MIF (0.66) | MIFMEN1KMT2ACTDSP1PIN1 | |
| SCHEMBL2589303 | 0.85 | MIF (0.46) | MIFMEN1KMT2ACTDSP1PIN1 | |
| SCHEMBL2589301 | 0.85 | MIF (0.46) | MIFMEN1KMT2ACTDSP1PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761080-A | Benzothia (di) azepin compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114761018-A | Benzothiadiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-113677398-A | Benzothiadiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2021-11-19 | — | — | CN | disclosed |
| EP-0775126-B1 | HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES | WELLCOME FOUND (GB) | 2002-10-30 | — | — | EP | disclosed |
| EP-0683774-B1 | HYPOLIPIDAEMIC COMPOUNDS | WELLCOME FOUND (GB) | 2002-10-09 | — | — | EP | disclosed |
| EP-1203769-A1 | Hypolipidemic 1,4-benzothiazepine derivative | THE WELLCOME FOUNDATION LIMITED (GB) | 2002-05-08 | — | — | EP | disclosed |
| US-5910494-A | NOVEL COMPOUNDS THAT REDUCE THE ABSORPTION OF BILE ACIDS FROM THE INTESTINE; FOR PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS, SUCH AS ATHEROSCLEROSIS | GLAXO WELLCOME INC. (US) | 1999-06-08 | — | — | US | disclosed |
| WO-1998038182-A9 | HYPOLIPIDEMIC BICYCLIC DERIVATIVES | GLAXO GROUP LTD (GB) | 1999-04-15 | — | — | WO | disclosed |
| EP-0626952-B1 | HYPOLIPIDAEMIC BENZOTHIAZEPINE COMPOUNDS | WELLCOME FOUND (GB) | 1999-04-14 | — | — | EP | disclosed |
| US-5859240-A | REDUCTION OF IMINE GROUP; OXIDATION; SALT FORMATION | GLAXO WELLCOME INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5723458-A | 1,4-BENZOTHIAZEPINES | GLAXO WELLCOME INC. (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0683773-B1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES | WELLCOME FOUND (GB) | 1997-09-17 | — | — | EP | disclosed |
| US-5663165-A | ANTICHOLESTEROL, CARDIOVASCULAR | GLAXO WELLCOME INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0775126-A1 | HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005188-A1 | HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |
| EP-0683774-A1 | HYPOLIPIDAEMIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-29 | — | — | EP | disclosed |
| EP-0626952-A1 | HYPOLIPIDAEMIC BENZOTHIAZEPINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994018184-A1 | HYPOLIPIDAEMIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-08-18 | — | — | WO | disclosed |
| WO-1994018183-A1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-08-18 | — | — | WO | disclosed |
| WO-1993016055-A1 | HYPOLIPIDAEMIC BENZOTHIAZEPINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |