Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306398 | 1.00 | MIF (0.50) | MIFPOLBMEN1KMT2ACTDSP1 | |
| SCHEMBL2589303 | 0.92 | MIF (0.46) | MIFPOLBMEN1KMT2ACTDSP1 | |
| SCHEMBL6838827 | 0.92 | MIF (0.46) | MIFPOLBMEN1KMT2ACTDSP1 | |
| SCHEMBL2589301 | 0.92 | MIF (0.46) | MIFPOLBMEN1KMT2ACTDSP1 | |
| SCHEMBL7468742 | 0.88 | MIF (0.58) | MIFMEN1KMT2ACTDSP1NPC1 | |
| SCHEMBL7468752 | 0.88 | MIF (0.58) | MIFMEN1KMT2ACTDSP1NPC1 | |
| SCHEMBL3233810 | 0.85 | MIF (0.43) | MIFPOLBMEN1KMT2ACTDSP1 | |
| SCHEMBL20848265 | 0.85 | MIF (0.44) | MIFPOLBMEN1KMT2ACTDSP1 | |
| SCHEMBL11114799 | 0.85 | MIF (0.43) | MIFPOLBMEN1KMT2ACTDSP1 | |
| SCHEMBL3233807 | 0.85 | MIF (0.43) | MIFPOLBMEN1KMT2ACTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004963-A | TUMOR NECROSIS FACTOR RELEASE INHIBITORS; IMMUNOMODULATORS | GRUENENTHAL GMBH (DE) | 1999-12-21 | — | — | US | disclosed |