Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 14/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 13/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.56 |
| ▸ | TDP2 | O95551 | 2/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1875587 | 0.83 | CYP11B1 (0.78) | CYP11B2CYP11B1CYP1A2CYP19A1TDP2 | |
| SCHEMBL1875324 | 0.81 | CYP11B2 (0.64) | CYP11B2CYP11B1CYP1A2CYP19A1TDP2 | |
| SCHEMBL1877569 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1CYP1A2CYP19A1TDP2 | |
| SCHEMBL1881216 | 0.78 | CYP11B1 (0.80) | CYP11B2CYP11B1CYP1A2CYP19A1TDP2 | |
| SCHEMBL3659028 | 0.75 | CYP11B1 (0.79) | CYP11B2CYP11B1CYP1A2CYP19A1TDP2 | |
| SCHEMBL29849907 | 0.75 | CYP11B1 (1.00) | CYP11B2CYP11B1CYP1A2TDP2PDE3B | |
| SCHEMBL748904 | 0.75 | CYP11B1 (1.00) | CYP11B2CYP11B1CYP1A2TDP2PDE3B | |
| SCHEMBL29849827 | 0.75 | CYP11B1 (1.00) | CYP11B2CYP11B1CYP1A2TDP2PDE3B | |
| SCHEMBL29899595 | 0.75 | CYP11B1 (1.00) | CYP11B2CYP11B1CYP1A2TDP2PDE3B | |
| SCHEMBL29899622 | 0.75 | CYP11B1 (0.79) | CYP11B2CYP11B1CYP1A2CYP19A1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430011-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130794-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | NOVARTIS AG (CH) | 2010-11-18 | — | — | WO | disclosed |