Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606016 | 0.85 | KDM1A (0.40) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 | |
| SCHEMBL5241041 | 0.83 | ALDH1A1 (0.44) | POLBKDM4ETSHRALDH1A1MAPT | |
| SCHEMBL7151009 | 0.80 | AOC3 (0.49) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 | |
| Formaldehyde SCHEMBL5244081 | 0.80 | ALDH1A1 (0.42) | POLBKDM4ETSHRALDH1A1MAPT | |
| SCHEMBL900889 | 0.78 | AOC3 (0.50) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 | |
| SCHEMBL775238 | 0.77 | AOC3 (0.53) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 | |
| SCHEMBL5580537 | 0.77 | AOC3 (0.49) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 | |
| SCHEMBL30883 | 0.75 | AOC3 (0.55) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 | |
| SCHEMBL20573182 | 0.75 | AOC3 (0.51) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 | |
| SCHEMBL27943252 | 0.75 | AOC3 (0.44) | AOC3SMN1; SMN2POLBCYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429292-A1 | COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR THE TREATMENT OF CANCER | Georgia State University Research Foundation, Inc. (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010129858-A1 | COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR THE TREATMENT OF CANCER | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-11-11 | — | — | WO | claimed |