Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469615 | 1.00 | ESR1 (0.38) | ESR1ESR2NR3C2HDAC6FFAR4 | |
| SCHEMBL8564189 | 0.85 | ESR1 (0.41) | ESR1ESR2NR3C2HDAC6ABHD6 | |
| SCHEMBL8564198 | 0.85 | ESR1 (0.41) | ESR1ESR2NR3C2HDAC6ABHD6 | |
| SCHEMBL8567424 | 0.82 | ESR1 (0.40) | ESR1ESR2HDAC6ABHD6 | |
| SCHEMBL8567428 | 0.82 | ESR1 (0.40) | ESR1ESR2HDAC6ABHD6 | |
| SCHEMBL8568715 | 0.81 | F10 (0.39) | ESR1ESR2 | |
| SCHEMBL8561412 | 0.81 | ESR1 (0.41) | ESR1ESR2HDAC6ABHD6 | |
| SCHEMBL8568710 | 0.81 | F10 (0.39) | ESR1ESR2 | |
| SCHEMBL8561418 | 0.81 | ESR1 (0.41) | ESR1ESR2HDAC6ABHD6 | |
| SCHEMBL8562237 | 0.80 | ESR1 (0.39) | ESR1ESR2HDAC6BACE1ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |