Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.46 |
| ▸ | TTR | P02766 | 3/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | ESRRA | P11474 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | MAX | P61244 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469695 | 1.00 | GSK3B (0.53) | GSK3BPIM1PIM2TTRCISD1 | |
| SCHEMBL7468657 | 0.88 | GSK3B (0.59) | GSK3BPIM1PIM2TTRCISD1 | |
| SCHEMBL7468651 | 0.88 | GSK3B (0.59) | GSK3BPIM1PIM2TTRCISD1 | |
| SCHEMBL7459436 | 0.88 | TTR (0.50) | GSK3BPIM1PIM2TTRCISD1 | |
| SCHEMBL7459431 | 0.88 | TTR (0.50) | GSK3BPIM1PIM2TTRCISD1 | |
| SCHEMBL7464157 | 0.87 | PIM2 (0.48) | PIM1PIM2TTRCISD1PTPN1 | |
| SCHEMBL7464163 | 0.87 | PIM2 (0.48) | PIM1PIM2TTRCISD1PTPN1 | |
| SCHEMBL7464545 | 0.87 | GSK3B (0.57) | GSK3BPIM1PIM2TTRCISD1 | |
| SCHEMBL7464547 | 0.87 | GSK3B (0.57) | GSK3BPIM1PIM2TTRCISD1 | |
| SCHEMBL7468503 | 0.86 | PIM1 (0.49) | PIM1PIM2TTRCISD1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | disclosed |