Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 8/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471273 | 0.93 | HTR1A (0.58) | KCNH2HTR1AHTR7 | |
| SCHEMBL7466735 | 0.87 | KCNH2 (0.53) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7471185 | 0.85 | HTR1A (0.61) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7466197 | 0.84 | HTR1A (0.57) | KCNH2HTR1AHTR7 | |
| SCHEMBL7469705 | 0.84 | HTR1A (0.58) | KCNH2HTR1AHTR7 | |
| SCHEMBL7464090 | 0.84 | KCNH2 (0.44) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7469317 | 0.83 | HTR1A (0.56) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7470345 | 0.82 | HTR1A (0.66) | HTR1ADRD2HTR7DRD3 | |
| SCHEMBL7469017 | 0.82 | HTR1A (0.64) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7471198 | 0.80 | HTR1A (0.48) | KCNH2HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755930-B1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6337397-B1 | A BENZOXAZEPINE DERIVATIVE FOR TREATMENT OF ANXIETY NEUROSIS, PHOBIAS, OBSESSIVE-COMPULSIVE DISORDERS, SCHIZOPHRENIA, POST-CARDIAC TRAUMA STRESS DISORDERS, DEPRESSION DISORDERS, PSYCHOSOMATIC DISORDERS AND OTHER PSYCHONEUROTIC DISORDERS, | SUNTORY LIMITED (JP) | 2002-01-08 | — | — | US | disclosed |
| US-6187769-B1 | Benzoxazepine derivatives and their salts and medicaments containing the same | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0755930-A1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |