Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 8/20 | 0.57 |
| ▸ | BCR | P11274 | 5/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15966728 | 0.85 | IGF1R (0.53) | CDK2CCNT1CCNA2CDK9CCNA1 | |
| SCHEMBL4467313 | 0.82 | CDK2 (0.83) | CDK2CCNT1CCNA2CDK9CCNA1 | |
| SCHEMBL14021608 | 0.82 | JAK2 (0.67) | CDK2CCNT1CCNA2CDK9CCNA1 | |
| SCHEMBL22686468 | 0.81 | ABL1 (0.58) | ABL1BCREGFRSRCPDGFRA | |
| SCHEMBL7474316 | 0.81 | HDAC1 (0.68) | CDK2ABL1BCRHDAC1EGFR | |
| SCHEMBL12423138 | 0.81 | IKBKB (0.59) | CDK2CCNT1CCNA2CDK9CCNA1 | |
| SCHEMBL14021247 | 0.81 | JAK2 (0.66) | CDK2CCNT1CCNA2CDK9CCNA1 | |
| SCHEMBL7474933 | 0.80 | ABL1 (0.68) | JAK2JAK3ABL1BCREGFR | |
| SCHEMBL16332645 | 0.80 | IGF1R (0.45) | CDK2CCNT1CCNA2CDK9CCNA1 | |
| SCHEMBL7467179 | 0.79 | ABL1 (0.69) | CDK2CCNT1CCNA2CDK9ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1703405-A | Aminobenzamide derivatives as glycogen synthase kinase 3 beta inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-11-30 | — | — | CN | claimed |
| CN-100436427-C | Aminobenzamide derivatives as glycogen synthase kinase 3 beta inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-26 | — | — | CN | disclosed |
| CN-1703405-A | Aminobenzamide derivatives as glycogen synthase kinase 3 beta inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-11-30 | — | — | CN | disclosed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |