Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.69 |
| ▸ | PRKCA | P17252 | 7/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.69 |
| ▸ | EGFR | P00533 | 2/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | BCR | P11274 | 14/20 | 0.63 |
| ▸ | SRC | P12931 | 4/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
| ▸ | PRKCB | P05771 | 1/20 | 0.58 |
| ▸ | PRKCH | P24723 | 1/20 | 0.58 |
| ▸ | PRKCI | P41743 | 1/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11924741 | 0.90 | MAPK8 (0.76) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| SCHEMBL210190 | 0.88 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| SCHEMBL7474316 | 0.88 | HDAC1 (0.68) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| SCHEMBL4903328 | 0.87 | MAPK8 (0.81) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| SCHEMBL7470849 | 0.87 | ABL1 (0.69) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| Hydrochloric Acid SCHEMBL7470853 | 0.87 | ABL1 (0.74) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| SCHEMBL7465651 | 0.87 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| SCHEMBL7465138 | 0.86 | ABL1 (0.80) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL7464205 | 0.84 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRHDAC1 | |
| SCHEMBL4903136 | 0.83 | PDGFRA (0.82) | ABL1PRKCAPRKCDEGFRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |