Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3327193 | 0.84 | TRPV1 (0.44) | TRPV1CYP3A4 | |
| SCHEMBL3327189 | 0.84 | TRPV1 (0.44) | TRPV1CYP3A4 | |
| SCHEMBL7479500 | 0.80 | HTR2C (0.42) | HTR2BHTR2CHTR1ASLC6A2SIGMAR1 | |
| SCHEMBL20616572 | 0.80 | TRPV1 (0.39) | TRPV1LMNAMAOBMAOA | |
| SCHEMBL15075066 | 0.80 | TRPV1 (0.39) | TRPV1LMNAMAOBMAOA | |
| SCHEMBL27492224 | 0.78 | HTR1A (0.37) | HTR2BHTR2CHTR1ASLC6A2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6561142 | 0.78 | HTR2C (0.41) | HTR2BHTR2CHTR1ASLC6A2SIGMAR1 | |
| SCHEMBL4350339 | 0.76 | KDM4E (0.48) | HTR2BHTR2CHTR1ASLC6A2SIGMAR1 | |
| SCHEMBL8476430 | 0.75 | HTR1A (0.36) | HTR2BHTR2CHTR1ASLC6A2SIGMAR1 | |
| SCHEMBL3319723 | 0.75 | TRPV1 (0.42) | HTR2BHTR2CTRPV1HTR2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| CN-1212964-A | Sulfonic acid amide substituted benzodihydropyrane processes for their preparation, their use as medicament and pharmaceutical preparations comprising them | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-04-07 | — | — | CN | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |