Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 3/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558722 | 0.90 | KCNE1 (0.48) | KCNE1KCNQ1TRPV1AKR1B1CYP3A4 | |
| SCHEMBL7474755 | 0.89 | KCNE1 (0.43) | KCNE1KCNQ1TRPV1CYP3A4 | |
| SCHEMBL7468526 | 0.88 | KCNE1 (0.49) | KCNE1KCNQ1TRPV1AKR1B1CYP3A4 | |
| SCHEMBL7471976 | 0.86 | KCNE1 (0.33) | KCNE1KCNQ1AKR1B1CYP3A4 | |
| SCHEMBL6559266 | 0.85 | KCNE1 (0.52) | KCNE1KCNQ1TRPV1AKR1B1CYP3A4 | |
| SCHEMBL6559250 | 0.85 | KCNE1 (0.44) | KCNE1KCNQ1TRPV1CYP3A4 | |
| SCHEMBL7474635 | 0.83 | KCNE1 (0.48) | KCNE1KCNQ1TRPV1AKR1B1CYP3A4 | |
| SCHEMBL6559927 | 0.81 | KCNA5 (0.41) | KCNE1KCNQ1 | |
| SCHEMBL8479232 | 0.80 | KCNE1 (0.47) | KCNE1KCNQ1TRPV1AKR1B1CYP3A4 | |
| SCHEMBL7473827 | 0.80 | KCNA5 (0.38) | KCNE1KCNQ1TRPV1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |