Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | MYC | P01106 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461489 | 0.84 | MAPT (0.67) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL7457358 | 0.84 | MEN1 (0.60) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL7461237 | 0.82 | MAPT (0.50) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL7463669 | 0.82 | MEN1 (0.49) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4659943 | 0.79 | KMT2A (0.49) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4659942 | 0.79 | KMT2A (0.49) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL7462857 | 0.78 | LMNA (0.62) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL1388454 | 0.78 | MCL1 (0.51) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL1388456 | 0.78 | MCL1 (0.51) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL7471065 | 0.78 | MCL1 (0.51) | MEN1KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | claimed |
| EP-0700388-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-03-13 | — | — | EP | claimed |
| WO-1995026341-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-10-05 | — | — | WO | claimed |
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-5652250-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1997-07-29 | — | — | US | disclosed |
| EP-0700388-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-03-13 | — | — | EP | disclosed |
| WO-1995026341-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-10-05 | — | — | WO | disclosed |