Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17843957 | 1.00 | MAP3K7 (0.39) | MAP3K7TAB1KDM4EALDH1A1GAA | |
| SCHEMBL21001997 | 0.80 | MAP3K7 (0.36) | MAP3K7TAB1KDM4EALDH1A1GAA | |
| SCHEMBL20524312 | 0.77 | NFKB1 (0.39) | MAP3K7TAB1KDM4EALDH1A1GAA | |
| SCHEMBL20524343 | 0.77 | NFKB1 (0.39) | MAP3K7TAB1KDM4EALDH1A1GAA | |
| SCHEMBL7489005 | 0.77 | NFKB1 (0.39) | MAP3K7TAB1KDM4EALDH1A1GAA | |
| SCHEMBL11557166 | 0.74 | CA1 (0.39) | MAP3K7TAB1KDM4ECA1CA2 | |
| SCHEMBL11557165 | 0.74 | CA1 (0.39) | MAP3K7TAB1KDM4ECA1CA2 | |
| SCHEMBL21002000 | 0.69 | CA1 (0.35) | MAP3K7TAB1KDM4EALDH1A1GAA | |
| SCHEMBL13167161 | 0.69 | P4HTM (0.38) | MAP3K7TAB1KDM4EALDH1A1GAA | |
| SCHEMBL8913948 | 0.69 | MEN1 (0.51) | KDM4EALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |