SCHEMBL7470516

SCHEMBL7470516

CCC1(CC)CSc2cc(OC)c(OC)cc2C(c2ccccc2)N1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC10A2 Q12908 19/20 0.53
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2582109 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL7472527 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL7472523 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL2581999 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL8798740 0.91 SLC10A2 (0.47) SLC10A2MEN1KMT2A
SCHEMBL8245819 0.88 SLC10A2 (0.48) SLC10A2
SCHEMBL8245823 0.88 SLC10A2 (0.48) SLC10A2
SCHEMBL8228356 0.88 SLC10A2 (0.49) SLC10A2
SCHEMBL8228357 0.88 SLC10A2 (0.49) SLC10A2
SCHEMBL7484804 0.85 SLC10A2 (0.43) SLC10A2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0775126-B1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES WELLCOME FOUND (GB) 2002-10-30 EP claimed
EP-3924490-A1 METHODS FOR TREATING CHOLESTASIS Mirum Pharmaceuticals, Inc. (US) 2021-12-22 EP disclosed
WO-2020167958-A1 METHODS FOR TREATING CHOLESTASIS MIRUM PHARMACEUTICALS, INC. (US) 2020-08-20 WO disclosed
WO-2015065983-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF GASTROINTESTINAL INFECTIONS Lumena Pharmaceuticals, Inc. (US) 2015-05-07 WO disclosed
EP-2771003-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES Lumena Pharmaceuticals, Inc. (US) 2014-09-03 EP disclosed
EP-2770990-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE Lumena Pharmaceuticals, Inc. (US) 2014-09-03 EP disclosed
EP-2739286-A2 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PANCREATITIS Lumena Pharmaceuticals, Inc. (US) 2014-06-11 EP disclosed
WO-2013063526-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE Lumena Pharmaceuticals, Inc. (US) 2013-05-02 WO disclosed
WO-2013063512-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES LUMENA PHARMACEUTICALS, INC (US) 2013-05-02 WO disclosed
EP-2575821-A2 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS Satiogen Pharmaceuticals, Inc. (US) 2013-04-10 EP disclosed
WO-2013020108-A2 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PANCREATITIS Lumena Pharmaceuticals, Inc. (US) 2013-02-07 WO disclosed
WO-2011150286-A2 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS SATIOGEN PHARMACEUTICALS,INC. (US) 2011-12-01 WO disclosed
EP-0971744-A2 COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 2000-01-19 EP disclosed
WO-1998040375-A2 COMBINATION OF ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 1998-09-17 WO disclosed
EP-0775126-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1997-05-28 EP disclosed
WO-1996005188-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1996-02-22 WO disclosed