Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.81 |
| ▸ | ABL1 | P00519 | 2/20 | 0.69 |
| ▸ | EGFR | P00533 | 2/20 | 0.69 |
| ▸ | PRKCA | P17252 | 1/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.69 |
| ▸ | DKK1 | O94907 | 2/20 | 0.69 |
| ▸ | GSK3B | P49841 | 2/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.63 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | PRKACG | P22612 | 1/20 | 0.60 |
| ▸ | PRKACB | P22694 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3519939 | 0.90 | IKBKB (1.00) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL3519764 | 0.88 | IKBKB (0.97) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL7471938 | 0.86 | ABL1 (0.70) | IKBKBABL1EGFRPRKCAPRKCD | |
| SCHEMBL4146725 | 0.85 | ABL1 (0.66) | IKBKBABL1EGFRPRKCAPRKCD | |
| SCHEMBL4148374 | 0.84 | HDAC3 (0.64) | IKBKBABL1EGFRPRKCAPRKCD | |
| SCHEMBL3868291 | 0.84 | ABL1 (0.76) | IKBKBABL1EGFRPRKCAPRKCD | |
| SCHEMBL3518422 | 0.84 | IKBKB (0.64) | IKBKBABL1PRKCAPRKCDDKK1 | |
| SCHEMBL14499929 | 0.83 | DKK1 (0.58) | IKBKBABL1EGFRPRKCAPRKCD | |
| SCHEMBL3520123 | 0.83 | IKBKB (0.74) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL3521072 | 0.83 | IKBKB (0.74) | IKBKBDKK1GSK3BMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |