Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 6/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472619 | 0.93 | KMT2A (0.39) | KMT2AACHETLR7HSD11B1TLR9 | |
| SCHEMBL7907325 | 0.84 | KMT2A (0.49) | KMT2AACHETLR7SMN1; SMN2HSD11B1 | |
| SCHEMBL11919045 | 0.82 | KMT2A (0.56) | KMT2AACHESMN1; SMN2HSD11B1CHRM4 | |
| SCHEMBL23732169 | 0.80 | KMT2A (0.46) | KMT2AACHETLR7SMN1; SMN2HSD11B1 | |
| SCHEMBL7907323 | 0.80 | KMT2A (0.46) | KMT2ATLR7HSD11B1TLR9 | |
| SCHEMBL13088144 | 0.78 | HSD11B1 (0.48) | KMT2ATLR7HSD11B1 | |
| SCHEMBL7899320 | 0.78 | HSD11B1 (0.48) | KMT2ATLR7HSD11B1 | |
| SCHEMBL11919058 | 0.78 | KMT2A (0.56) | KMT2AACHESMN1; SMN2CHRM4 | |
| SCHEMBL18874058 | 0.77 | KMT2A (0.44) | KMT2AACHETLR7SMN1; SMN2HSD11B1 | |
| SCHEMBL10281974 | 0.77 | KMT2A (0.47) | KMT2AACHETLR7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858452-B1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-6140330-A | USEFUL AS PROTEIN KINASE INHIBITOR; FOR TREATMENT OF AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS, MULTIPLE SCLEROSIS, PSORIASIS, ETC., VARIOUS ALLERGIC DISEASES SUCH AS CROHN'S DISEASE, ASTHMA | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-10-31 | — | — | US | disclosed |
| EP-0858452-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | disclosed |
| WO-1998004536-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-02-05 | — | — | WO | disclosed |