SCHEMBL7471817

SCHEMBL7471817

O=C(O)C1CCCN(CCBr)C1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A1 P30531 4/20 0.52
ALDH1A1 P00352 2/20 0.52
LMNA P02545 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
TSHR P16473 1/20 0.52
NFKB1 P19838 1/20 0.52
CYP2C19 P33261 1/20 0.52
HSD17B10 Q99714 1/20 0.52
SLC6A11 P48066 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7471811 1.00 SLC6A1 (0.52) SLC6A1ALDH1A1LMNACYP1A2CYP2D6
Bromide SCHEMBL7477000 0.98 SLC6A1 (0.51) SLC6A1ALDH1A1LMNACYP1A2CYP2D6
Bromide SCHEMBL7472898 0.98 SLC6A1 (0.51) SLC6A1ALDH1A1LMNACYP1A2CYP2D6
SCHEMBL3865049 0.85 SLC6A1 (0.55) SLC6A1ALDH1A1LMNACYP1A2CYP2D6
SCHEMBL28959996 0.85 BCHE (0.55) CYP1A2CYP2D6CYP2C9TSHRNFKB1
SCHEMBL3840286 0.84 SLC6A1 (0.54) SLC6A1ALDH1A1LMNACYP1A2CYP2D6
SCHEMBL3839566 0.84 SLC6A1 (0.54) SLC6A1ALDH1A1LMNACYP1A2CYP2D6
SCHEMBL3841038 0.84 SLC6A1 (0.54) SLC6A1ALDH1A1LMNACYP1A2CYP2D6
SCHEMBL3844126 0.83 CYP1A2 (0.50) CYP1A2CYP2D6CYP2C9TSHRNFKB1
SCHEMBL10180992 0.82 SLC6A1 (0.52) SLC6A1ALDH1A1LMNACYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5608069-A TREATMENT OF NERVOUS SYSTEM DISORDERS WITH GAMMA-AMINOBUTYRIC ACID NOVO NORDISK A/S (DK) 1997-03-04 US disclosed
EP-0705246-A1 N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF NOVO NORDISK A/S (DK) 1996-04-10 EP disclosed
WO-1995000483-A1 N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF NOVO NORDISK A/S (DK) 1995-01-05 WO disclosed