Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 10/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562890 | 0.86 | GRIA4 (0.51) | GRIA4GRIA2GRIA1CA12CA2 | |
| SCHEMBL5186022 | 0.82 | GRIA4 (0.62) | GRIA4GRIA2GRIA1CA12CA2 | |
| SCHEMBL171653 | 0.81 | CA2 (0.61) | GRIA4CA12CA2CA7CA14 | |
| SCHEMBL5186027 | 0.80 | GRIA1 (0.52) | GRIA4GRIA1KMT2AMEN1 | |
| SCHEMBL16088856 | 0.79 | KMT2A (0.56) | GRIA4CA12KMT2AMEN1 | |
| SCHEMBL2574235 | 0.79 | KMT2A (0.55) | CA12CA2CA7CA14KMT2A | |
| SCHEMBL27428116 | 0.78 | GRIA4 (0.38) | GRIA4GRIA2CA12CA2CA7 | |
| SCHEMBL12265804 | 0.78 | SMN1; SMN2 (0.54) | — | |
| SCHEMBL777415 | 0.78 | CA9 (0.51) | GRIA4GRIA2CA12CA2CA7 | |
| SCHEMBL5186107 | 0.76 | GRIA4 (0.35) | GRIA4GRIA2GRIA1GRIA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | claimed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | claimed |
| US-6174922-B1 | FOR POTENTIATING GLUTAMATE RECEPTOR FUNCTION IN WARM BLOODED MAMMAL | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | claimed |
| WO-1999043285-A2 | SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1999-09-02 | — | — | WO | claimed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | claimed |
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6174922-B1 | FOR POTENTIATING GLUTAMATE RECEPTOR FUNCTION IN WARM BLOODED MAMMAL | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| WO-1999043285-A2 | SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1999-09-02 | — | — | WO | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |