Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.40 |
| ▸ | PFKFB4 | Q16877 | 5/20 | 0.40 |
| ▸ | CMA1 | P23946 | 6/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956129 | 0.88 | NPSR1 (0.45) | NPSR1L3MBTL1HTR6KDM4EAKR1B1 | |
| SCHEMBL337593 | 0.80 | NPSR1 (0.62) | NPSR1L3MBTL1KDM4EAKR1B1PFKFB3 | |
| SCHEMBL3686803 | 0.76 | KDM4E (0.46) | NPSR1L3MBTL1KDM4EAKR1B1PFKFB3 | |
| SCHEMBL7539216 | 0.76 | NPSR1 (0.45) | NPSR1L3MBTL1HTR6KDM4EAKR1B1 | |
| SCHEMBL3683337 | 0.73 | KDM4E (0.43) | NPSR1L3MBTL1KDM4EAKR1B1PFKFB3 | |
| SCHEMBL13508313 | 0.71 | NPSR1 (0.58) | NPSR1L3MBTL1HTR6AKR1B1PFKFB3 | |
| SCHEMBL13696908 | 0.70 | NPSR1 (0.62) | NPSR1L3MBTL1HTR6AKR1B1PFKFB3 | |
| SCHEMBL788639 | 0.70 | NPSR1 (0.48) | NPSR1L3MBTL1HTR6AKR1B1PFKFB3 | |
| SCHEMBL1548591 | 0.70 | NPSR1 (0.62) | NPSR1L3MBTL1HTR6AKR1B1PFKFB3 | |
| SCHEMBL3689324 | 0.70 | KDM4E (0.46) | NPSR1L3MBTL1HTR6KDM4EAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |