Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18639248 | 0.88 | KDM4E (0.46) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL5971405 | 0.88 | KDM4E (0.46) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL9391758 | 0.86 | KDM4E (0.45) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL7818342 | 0.86 | KDM4E (0.45) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3485394 | 0.86 | KDM4E (0.43) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL8518648 | 0.78 | TAAR1 (0.36) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL14817427 | 0.77 | KCNA3 (0.48) | HRH4HRH3ENPP2MCL1KDM4E | |
| Hydrochloric Acid SCHEMBL28010546 | 0.76 | TAAR1 (0.35) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL10793012 | 0.75 | MCL1 (0.43) | HRH4HRH3ENPP2MCL1KDM4E | |
| SCHEMBL25987505 | 0.75 | KCNA3 (0.43) | HRH4HRH3ENPP2MCL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058678-B1 | METAL-CATALYZED ARYLATIONS AND VINYLATIONS OF HYDRAZINES, HYDRAZONES, HYDROXYLAMINES AND OXIMES | MASSACHUSETTS INST TECHNOLOGY (US) | 2002-12-11 | — | — | EP | disclosed |
| US-6465693-B2 | TRANSITION METAL CATALYZED ARYLATION OR VINYLATION; COMBINATORIAL CHEMISTRY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-10-15 | — | — | US | disclosed |
| US-20010031894-A1 | Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates | BUCHWALD STEPHEN L (US) | 2001-10-18 | — | — | US | disclosed |
| US-6235936-B1 | TRANSITION METAL CATALYST FOR ARYLATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2001-05-22 | — | — | US | disclosed |
| EP-1058678-A2 | METAL-CATALYZED ARYLATIONS AND VINYLATIONS OF HYDRAZINES, HYDRAZONES, HYDROXYLAMINES AND OXIMES | Massachusetts Institute of Technology (US) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999043643-A2 | METAL-CATALYZED ARYLATIONS AND VINYLATIONS OF HYDRAZINES, HYDRAZONES, HYDROXYLAMINES AND OXIMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010031894-A1 | Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates | IDO1, IDO2, AHR | HRH4 401/4885HRH3 724/4885ENPP2 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.