Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18639248 | 0.98 | KDM4E (0.46) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL5971405 | 0.98 | KDM4E (0.46) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL7818342 | 0.96 | KDM4E (0.45) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL9391758 | 0.96 | KDM4E (0.45) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL8518648 | 0.91 | TAAR1 (0.36) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL7472203 | 0.86 | HRH4 (0.40) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL22634123 | 0.81 | SLC18A3 (0.45) | MEN1KMT2ALMNACYP2D6 | |
| SCHEMBL8534401 | 0.78 | CHRM1 (0.49) | KDM4EMEN1KMT2ASMN1; SMN2PKM | |
| SCHEMBL28581310 | 0.76 | KDM4E (0.46) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL218047 | 0.76 | KCNA3 (0.50) | KDM4EMEN1KMT2AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3439658-B1 | SOLUBLE C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2021-11-24 | — | — | EP | disclosed |
| WO-2017176620-A2 | SOLUBLE C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2017-10-12 | — | — | WO | disclosed |
| US-20100234409-A1 | Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2010-09-16 | — | — | US | disclosed |
| EP-1753740-A2 | AMINO CYCLOPENTYL HETEROCYCLIC AND CARBOCYCLIC MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2006001958-A2 | AMINO CYCLOPENTYL HETEROCYCLIC AND CARBOCYCLIC MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2006-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234409-A1 | Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity | CXCR3, CXCR1, CCR2 | KDM4E 3897/4885MEN1 3621/4885KMT2A 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.