Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469531 | 0.96 | MEN1 (0.45) | MEN1KMT2AMAPTPOLBEGFR | |
| SCHEMBL14224502 | 0.83 | MAPT (0.49) | MEN1KMT2AMAPTPOLBEGFR | |
| SCHEMBL7466190 | 0.83 | EGFR (0.43) | MEN1KMT2AMAPTEGFRRAB9A | |
| SCHEMBL8603119 | 0.79 | SPHK2 (0.42) | EGFRRAB9ANPC1CNR1CNR2 | |
| SCHEMBL14224669 | 0.77 | MEN1 (0.49) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL5333969 | 0.76 | CHEK2 (0.47) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL5559865 | 0.76 | MEN1 (0.47) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL7471355 | 0.75 | MAPT (0.43) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL9028656 | 0.75 | HRAS (0.49) | MEN1KMT2AMAPTPOLBEGFR | |
| SCHEMBL7468134 | 0.74 | MAPT (0.49) | MEN1KMT2AMAPTPOLBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |