Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479357 | 0.91 | PARP15 (0.53) | PARP15PARP10GPR119SLC2A1STS | |
| SCHEMBL20231480 | 0.91 | GPR119 (0.54) | GPR119SLC2A1ALDH1A1CHEK2HDAC1 | |
| SCHEMBL22284267 | 0.89 | GPR119 (0.61) | GPR119STSALDH1A1EPHX2TGFBR1 | |
| SCHEMBL7394538 | 0.89 | GPR119 (0.52) | GPR119SLC2A1ALDH1A1CHEK2HDAC1 | |
| SCHEMBL7358039 | 0.84 | GPR119 (0.53) | GPR119STSALDH1A1CHEK2EPHX2 | |
| SCHEMBL30606457 | 0.84 | GPR119 (0.53) | GPR119STSALDH1A1CHEK2EPHX2 | |
| SCHEMBL16992177 | 0.83 | STS (0.47) | GPR119STSALDH1A1EPHX2TGFBR1 | |
| SCHEMBL3225627 | 0.83 | PARP10 (0.67) | PARP15PARP10ALDH1A1 | |
| SCHEMBL1475361 | 0.83 | KDM4E (0.54) | GPR119STSTGFBR1 | |
| SCHEMBL241130 | 0.83 | GPR119 (0.59) | GPR119SLC2A1ALDH1A1CHEK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714299-B1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-04-24 | — | — | EP | disclosed |
| US-5665719-A | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists | MERCK & CO., INC. (US) | 1997-09-09 | — | — | US | disclosed |