Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.81 |
| ▸ | USP2 | O75604 | 1/20 | 0.81 |
| ▸ | RECQL | P46063 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20448044 | 0.90 | SMN1; SMN2 (1.00) | SMN1; SMN2USP2RECQLTSHRPOLB | |
| SCHEMBL344191 | 0.88 | SMN1; SMN2 (0.96) | SMN1; SMN2USP2RECQLTSHRPOLB | |
| SCHEMBL7645826 | 0.85 | USP2 (0.58) | SMN1; SMN2USP2RECQLTSHRLMNA | |
| SCHEMBL7645820 | 0.85 | USP2 (0.58) | SMN1; SMN2USP2RECQLTSHRLMNA | |
| Acetic Acid SCHEMBL29118271 | 0.83 | SMN1; SMN2 (0.86) | SMN1; SMN2USP2RECQLTSHRPOLB | |
| SCHEMBL19353607 | 0.83 | USP2 (0.68) | SMN1; SMN2USP2RECQLTSHRRAB9A | |
| SCHEMBL2920417 | 0.81 | SMN1; SMN2 (0.83) | SMN1; SMN2USP2RECQLTSHRPOLB | |
| SCHEMBL392980 | 0.81 | SMN1; SMN2 (0.83) | SMN1; SMN2USP2RECQLTSHRPOLB | |
| SCHEMBL779445 | 0.81 | SMN1; SMN2 (0.76) | SMN1; SMN2USP2RECQLTSHRRAB9A | |
| SCHEMBL587550 | 0.81 | USP2 (0.58) | SMN1; SMN2USP2RECQLGPR119HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114656422-A | Novel aza crown ether compound and cationic liposome thereof, preparation method and application | 重庆理工大学 | 2022-06-24 | — | — | CN | claimed |
| CN-114656422-A | Novel aza crown ether compound and cationic liposome thereof, preparation method and application | 重庆理工大学 | 2022-06-24 | — | — | CN | disclosed |
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1216242-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| US-6355637-B1 | QUINAZOLONES FOR LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001025235-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |