Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645826 | 0.98 | USP2 (0.58) | USP2SMN1; SMN2RECQLKDM4EMAPT | |
| SCHEMBL7472743 | 0.85 | SMN1; SMN2 (0.81) | USP2SMN1; SMN2RECQLTSHRGPR119 | |
| SCHEMBL29988783 | 0.76 | USP2 (0.41) | USP2SMN1; SMN2RECQL | |
| SCHEMBL20448044 | 0.76 | SMN1; SMN2 (1.00) | USP2SMN1; SMN2RECQLTSHRGPR119 | |
| Hydrochloric Acid SCHEMBL29356070 | 0.75 | USP2 (0.40) | USP2SMN1; SMN2RECQL | |
| SCHEMBL344191 | 0.75 | SMN1; SMN2 (0.96) | USP2SMN1; SMN2RECQLTSHRGPR119 | |
| SCHEMBL9066841 | 0.73 | RECQL (0.49) | USP2SMN1; SMN2RECQLKDM4EMAPT | |
| SCHEMBL1560847 | 0.72 | USP2 (0.72) | USP2SMN1; SMN2RECQLKDM4EMAPT | |
| SCHEMBL25262250 | 0.71 | SSTR4 (0.48) | — | |
| Acetic Acid SCHEMBL29118271 | 0.70 | SMN1; SMN2 (0.86) | USP2SMN1; SMN2RECQLTSHRGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216242-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| US-6355637-B1 | QUINAZOLONES FOR LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001025235-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |