Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053005 | 0.79 | FGFR1 (0.59) | FGFR1 | |
| SCHEMBL9769510 | 0.79 | FGFR1 (0.44) | HTTFGFR1 | |
| SCHEMBL1803928 | 0.75 | HTT (0.55) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL31049319 | 0.74 | HTT (0.53) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL30402227 | 0.72 | HTT (0.88) | HTTPOLBFGFR1 | |
| SCHEMBL3419279 | 0.72 | HTT (0.88) | HTTPOLBFGFR1 | |
| SCHEMBL3417306 | 0.72 | HTT (0.73) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL24988386 | 0.72 | HTT (0.60) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL28580330 | 0.71 | MKNK2 (0.46) | FGFR1MKNK2 | |
| SCHEMBL9025863 | 0.71 | PIK3CB (0.68) | HTTPOLBFGFR1PIK3CBROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11189594-A | — | — | None | — | — | JP | disclosed |
| CN-114787136-A | Substituted benzimidazole carboxamides and their use in the treatment of medical disorders | 比亚尔R&D投资股份公司 | 2022-07-22 | — | — | CN | disclosed |
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| JP-H11189594-A | PYRROYLBENZIMIDAZOLE DERIVATIVE HAVING ACRYLIC ACID DERIVATIVE GROUP ON SIDE CHAIN | MITSUI CHEM INC | 1999-07-13 | — | — | JP | disclosed |
| EP-0776891-B1 | Pyrrolylbenzimidazole derivatives | MITSUI CHEMICALS INC (JP) | 1999-02-10 | — | — | EP | disclosed |
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5808087-A | ANTITUMOR, ANTICANCER AGENTS | MITSUI CHEMICALS, INC. (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0776891-A1 | Pyrrolylbenzimidazole derivatives | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1997-06-04 | — | — | EP | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |