Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | ELANE | P08246 | 1/20 | 0.59 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3785093 | 0.88 | ALDH1A1 (0.58) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL2860044 | 0.86 | KDM4E (0.68) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL31126834 | 0.86 | KDM4E (0.68) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL13502562 | 0.86 | ELANE (0.55) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL8239760 | 0.85 | SMN1; SMN2 (0.56) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL3783571 | 0.85 | KDM4E (0.78) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL3779399 | 0.84 | ALDH1A1 (0.57) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL3785102 | 0.84 | ALDH1A1 (0.60) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL3786372 | 0.84 | TSHR (0.50) | TSHRMAPK10ALDH1A1TDP1MAPK1 | |
| SCHEMBL27859823 | 0.81 | GAA (0.56) | TSHRMAPK10ALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |